888-237-3625 | 520-748-0388
ground and root ginger

Ginger in gastrointestinal disorders: A systematic review of clinical trials

Posted Jul 12, 2023

by Mehrnaz Nikkhah Bodagh et al.


Ginger, the rhizome of Zingiber officinale, is a member of the Zingiberaceae family that has been used as a spice globally. This spice contains a wide variety of volatile and nonvolatile compounds with various concentrations depending on different condition of cultivation, harvesting, and processing (Haniadka et al., 2013). Chemical analysis of ginger shows that it contains over 400 different compounds.

The major constituents in ginger rhizomes are carbohydrates (50–70%), lipids (3–8%), terpenes, and phenolic compounds (Grzanna, Lindmark, & Frondoza, 2005). Terpene components of ginger include zingiberene, β-bisabolene, α-farnesene, β-sesquiphellandrene, and α-curcumene, while phenolic compounds include gingerol, paradols, and shogaol.

The specific odor of ginger is related to zingiberene and bisabolene, while the pungent flavor is due to volatile oils of gingerols (23–25%) and shogaols (18–25%). Besides these components, amino acids, raw fiber, ash, protein, phytosterols, vitamins (e.g., nicotinic acid and vitamin A), and minerals are also present in ginger.

Other gingerol-or shogaol-related compounds (1–10%), which have been reported in ginger rhizome, include 6-paradol, 1-dehydrogingerdione, 6-gingerdione and 10-gingerdione, 4-gingerdiol, 6-gingerdiol, 8-gingerdiol, and 10-gingerdiol, and diarylheptanoids (Ali, Blunden, Tanira, & Nemmar, 2008; McGee, 2007; Prasad & Tyagi, 2015).

Since thousands of years ago, ginger has been used as a food and herbal medicine in Asia and the Far East so that its medical use is well described in Chinese remedies from 400 BC.

The rhizomes have been used since antiquity in the various traditional systems of medicine to treat cold, fever, sore throats, infectious diseases, arthritis, rheumatism, sprains, muscular aches, pains, cramps, hypertension, dementia, migraine, nervous diseases, gingivitis, toothache, asthma, stroke, and diabetes and also used as home remedy in treating various gastric ailments like constipation, diarrhea, dyspepsia, belching, bloating, gastritis, epigastric discomfort, gastric ulcerations, indigestion, nausea, and vomiting (Giacosa, Morazzoni, et al., 2015; Haniadka et al., 2013; Lete & Allué, 2016).

This long and established history of medicinal use of ginger in humans has stimulated clinical trials to scientifically assess the effectiveness of ginger as an adjuvant therapy or as a complementary and alternative medicine in a number of diseases especially gastrointestinal ailments (Lete & Allué, 2016).

Anti-inflammatory, antioxidant, antitumor, and antiulcer effects of ginger have been proven in some studies; however, some results are controversial, probably due to the chemical instability of gingerols (the ginger most active ingredients), which are readily oxidizable substances (Giacosa, Morazzoni, et al., 2015; Lete & Allué, 2016).

The U.S. Food and Drug Administration classifies ginger as “Generally Recognized as Safe” and the German Commission Monographs reported that ginger has no known side effects and no known drug/herb interactions (Blumenthal, 1998). In this review, we summarize recent studies evaluating the effects of ginger consumption in gastrointestinal disorders.


Ginger as an important dietary agent which possesses carminative effect, decreases pressure on lower esophageal sphincter, reduces intestinal cramping, and prevents dyspepsia, flatulence, and bloating (Ali et al., 2008; Chrubasik, Pittler, & Roufogalis, 2005; Lohsiriwat, Rukkiat, Chaikomin, & Leelakusolvong, 2010).

A clinical trial (Giacosa, Morazzoni, et al., 2015) investigated the effects of ginger extract (100 mg, corresponding to 2 g of rhizome twice a day) on gastrointestinal motility and showed a significant increase in gastrointestinal motility in the intervention group in comparison with the placebo (Micklefield et al., 1999).

Wu et al. (2008) showed that ginger accelerates gastric emptying and stimulates antral contractions in healthy individuals; studies on patients with functional dyspepsia have shown the same results with no alterations in the fundus dimension, gastrointestinal symptoms, or serum level of gut peptides such as GLP-1, motilin, and ghrelin (Hu et al., 2011). Impaired gastric emptying is a well-recognized contributor to the pathophysiology of gastrointestinal problems such as functional dyspepsia and nausea.

Functional dyspepsia is defined as postprandial fullness, early satiety, or epigastric pain/burning or discomfort centered in the upper abdomen in the absence of any known structural cause and without features of irritable bowel syndrome or gastroesophageal reflux; symptoms are frequently correlated to meals and may include abdominal pain, bloating, early satiety, fullness, belching, and nausea (Talley et al., 1999).

Prodigest is the standardized combination of ginger extracts and artichoke extract. Artichoke completes the effects of ginger because ginger is active on stomach while artichoke on small bowel. A randomized, 4-week trial on patients with functional dyspepsia showed that daily consumption of Prodigest before lunch and dinner resulted in a significant amelioration of functional dyspepsia symptoms including nausea, epigastric fullness, epigastric pain, and bloating as compared with placebo (Giacosa, Guido, et al., 2015).

A randomized crossover study investigated the effects of Prodigest on gastric emptying in 11 healthy volunteers. In this study, the baseline area of gastric volume was determined by ultrasonography 10 min before the main meal. Then, the subjects were given one Prodigest or placebo capsule and consumed a standardized meal.

One hour after the meal, the gastric volume was measured again. The gastric emptying was compared by differences between gastric volumes. Finally, the results indicated that the after-meal gastric area was significantly smaller, with a −24% difference, following the combination of extracts, as compared with placebo.

So, Prodigest significantly promotes gastric emptying in healthy volunteers without being associated with notable adverse effects (Lazzini, Polinelli, Riva, Morazzoni, & Bombardelli, 2016). These effects on gastric emptying are mostly dependent upon the peculiar molecular actions of the ginger extract.

Gastric hypomotility involves a temporary dysfunction of the integrated network of cholinergic M3 and serotonergic 5-HT3/5-HT4 receptors. The major chemical constituents of the ginger roots lipophilic extracts such as [6]-gingerol, [8]-gingerol, [10]-gingerol, and [6]-shogaol do modulate all these receptors (Giacosa, Guido, et al., 2015; Lazzini et al., 2016).

Delayed gastric emptying leads to gastric intolerance to gavages and increases gastric residual volume, vomiting, risk of aspiration, and the length of stay in hospital in 30–51% of the patients (Davies, 2010; Landzinski, Kiser, Fish, Wischmeyer, & MacLaren, 2008). Delayed gastric emptying and gastrointestinal motility disorder are the main gastrointestinal problem in the severely ill patients undergoing mechanical ventilation.

A double blind randomized controlled clinical trial showed that consumption of 120 mg ginger extract for 4 days significantly lowered mean residual volume of feeding with a standard gavage solution, on the fifth and the sixth days of feeding (Ghochae et al., 2013). Another study also showed that ginger extract increases the amount of tolerated food, and the amount of calorie intake in patients with adults respiratory distress syndrome under mechanical ventilation (Shariatpanahi, Taleban, Mokhtari, & Shahbazi, 2010).


The most common cause of nausea and vomiting is pregnancy. Nausea and vomiting affect up to 80% of women during the first trimester of pregnancy that range from morning sickness to hyperemesis gravidarum (HG) (Lete & Allué, 2016; McCarthy, Lutomski, & Greene, 2014; Palatty, Haniadka, Valder, Arora, & Baliga, 2013). Nonpharmacologic management of nausea in pregnancy includes avoiding nausea-inducing foods and eating small, frequent meals (Matthews, Dowswell, Haas, & O’Mathúna, 2010).

Administration of pyridoxine or doxylamine-pyridoxine might be beneficial. Medications such as dimenhydrinate, promethazine, ondansetron, or chlorpromazine can be used in severe cases, while 250 mg of ginger taken orally every 6 hr might be added at any time (Arsenault et al., 2002). The impact of ginger consumption as an antiemetic in nausea and vomiting of pregnancy has been extensively investigated in clinical studies for at least 30 years (Giacosa, Morazzoni, et al., 2015).

The studies have shown that ginger in dose of 1 g/day is effective in pregnancy nausea and vomiting with no significant side effects (Firouzbakht, Nikpour, Jamali, & Omidvar, 2014; Haji Seid Javadi, Salehi, & Mashrabi, 2013; Saberi, Sadat, Abedzadeh-Kalahroudi, & Taebi, 2014; Thomson, Corbin, & Leung,2014; Viljoen, Visser, Koen, & Musekiwa, 2014).

American College of Obstetricians and Gynecologists (ACOG), and the National Institute for Health and Clinical Excellence, has accepted ginger as a remedy for nausea and vomiting during early pregnancy (Giacosa, Morazzoni et al., 2015) (Table 1).

Another disturbing cause of nausea and vomiting is the side effects of chemotherapy (Ryan, 2010). Some chemotherapeutic agents, including cyclophosphamide and cisplatin, can lead to a high incidence of nausea and vomiting (Herrstedt & Dombernowsky, 2007).

The standard of care for chemotherapy-induced vomiting is antiemetics, most notably serotonin (5-HT3) receptor antagonists and glucocorticoids, such as dexamethasone; however, efforts to control nausea have not been successful (Bloechl-Daum, Deuson, Mavros, Hansen, & Herrstedt, 2006; Herrstedt & Roila, 2008).

The summary of studies evaluating the effects of ginger consumption on chemotherapy-related nausea and vomiting is shown in Table 2 (Ansari et al., 2016; Arslan & Ozdemir, 2015; Fahimi et al., 2011; Manusirivithaya et al., 2004; Marx et al., 2013; Montazeri, Raei, et al., 2013; Panahi et al., 2012; Pillai, Sharma, Gupta, & Bakhshi, 2011; Ryan et al., 2012; Sanaati, Najafi, Kashaninia, & Sadeghi, 2016; Sontakke, Thawani, & Naik, 2003; Thamlikitkul et al., 2017; Zick et al., 2009).

Nausea and vomiting can occur after surgery, medications, or even exercise. Despite advances in surgical techniques and introduction of less-emetogenic anesthetic methods and drugs, postoperative nausea and vomiting, which occurs within 24 hr after surgery, are one of the common and distressing symptoms, following anesthesia and surgery (Palatty et al., 2013).

The frequency of upper and lower gastrointestinal disturbance as a consequence of exercise is reported to be between 30 and 70%, with the severity of symptoms ranging from mild stomach discomfort to severe diarrhea (Ball, Ashley, & Stradling, 2015).

As it is shown in Table 3, 500 mg ginger per day can reduce postsurgery nausea and vomiting. Generally, the most common and well-established use of ginger is its utilization in alleviating symptoms of nausea and vomiting (Lete & Allué, 2016).

Although the included studies generally reported statistically significant reductions in nausea and vomiting measures, the clinical significance of these results was controversial, which could perhaps be explained by the nonstandardized preparations of ginger used and inconsistencies in study methods and outcomes. Multiple potential mechanisms of action have been identified including 5-HT3 receptor antagonism, anti-inflammatory properties, and the modulation of gastrointestinal motility (Marx, Kiss, & Isenring, 2015; Marx et al., 2013) (Table 4).


Nonalcoholic fatty liver disease (NAFLD) is one of chronic liver diseases throughout the world that mostly is seen in obese, low active people, and patients with type II diabetes (Ong & Younossi, 2007). There is no proven medical treatment for this disorder; however, following a healthy life style, modified diet and exercise are suggested by researchers (Thoma, Day, & Trenell, 2012).

Previous studies have shown that a diet rich in antioxidants and anti-inflammatory agents can be effective in the treatment of NAFLD (Eslamparast, Eghtesad, Poustchi, & Hekmatdoost, 2015). Rahimlou, Yari, Hekmatdoost, Alavian, & Keshavarz (2016) conducted the first randomized, double-blind clinical trial study that examined the effects of ginger supplementation with lifestyle intervention on liver enzymes, inflammatory markers, steatosis, and hepatic fibrosis scores in patients with nonalcoholic fatty liver disease (NAFLD).

In this study, 44 patients with NAFLD consumed 2 g of ginger supplement or placebo per day for 12 weeks. In both groups, patients were advised to follow a balanced diet and physical activity program and resulted in a significant decrease in inflammatory marker levels, liver enzymes, hepatic steatosis, and insulin resistance (that is one of the major risk factors in the pathogenesis of NAFLD) in ginger group.

Inflammatory cytokines such as TNF-a play critical role in development of insulin resistance and liver fibrosis and increase fatty acids oxidation. Active compounds in ginger can enhance the antioxidant defense systems such as glutathione peroxidase and glutathione S-transferase, and reduce levels of malondialdehyde (MDA) and hepatic steatosis.

Thus, reduction of TNF-α and other inflammatory factors resulted in improvement of the NAFLD characteristics. In this study, no significant decrease was observed in liver fibrosis score in the ginger group compared to the placebo group. This can be due to the short term of the intervention, because it takes a long time for regeneration of hepatic tissue and reduction of fibrotic tissue. Further RCTs are needed to find the mechanism of action and ideal dose of ginger supplementation for NAFLD management.


Irritable bowel syndrome (IBS) is a common functional chronic gastrointestinal disorder, consisting of abdominal discomfort with changes in bowel habits. The effectiveness of current therapeutic

strategies for IBS is limited and about 40% of patients use alternative medicine to treat their symptoms (Van Tilburg et al., 2008). Due to the known gastrointestinal effects of ginger, it was reported as the most popular remedy consumed, in a large study of 600 IBS patients (Van Tilburg, Palsson, Ringel, & Whitehead, 2014; Van Tilburg et al., 2008).

Van Tilburg et al. (2014) evaluated ginger for IBS treatment in a pilot study of 45 IBS patients, who were randomly consumed placebo, or 1 g of ginger, or 2 g of ginger daily for 28 days. Ginger was well tolerated but it did not show better effects in comparison with placebo. Since this is the first clinical trial on this topic and is a pilot study, it may not be powered enough to find significant results.

The investigators also examined trends of these effects, and they found a trend of more improvement of IBS symptoms with placebo (brown sugar) than ginger. The placebo response in this study was 57% with twice as many side effects as the ginger group. In this study, the efficacy of ginger decreased with increase in dosage (26% decrease in symptoms with 1 g versus 12% decrease in symptoms with 2 g of ginger). Optimal ginger dosing should be examined in future trials.


Nonsteroid anti-inflammatory drugs (NSAIDs) represent as an important and prevalent medicine with common side effects of gastrointestinal (GI) tract (Solomon & Goodson, 2007). (Drozdov, Kim, Tkachenko, & Varvanina (2012) investigated the GI health in 43 patients with confirmed osteoarthritis receiving 1000 mg glucosamine with either ginger (340 mg EV.EXT 35 Zingiber officinalis extract) or Diclofenac (a member of NSAIDs) per day for 4 weeks.

In this study, ginger group showed significantly lowered gastrointestinal pain and no change in dyspepsia but esophagogastroduodenoscopy showed significantly increased levels of prostaglandins (PGs) PGE1, PGE2, and PGF2a in the stomach mucosa.

This rise in gastric mucosa PG levels correlated with an increase in serum gastrin-17, whereas Diclofenac group showed increased gastrointestinal pain and dyspepsia with a corresponding significant decrease in stomach mucosa prostaglandins and general negative stomach mucosa degeneration. Both groups showed a relevant and significantly lowered arthritic pain, both on standing and moving, so that ginger was as effective as Diclofenac in reducing pain, while it was safer.


In a randomized clinical trial, 20 subjects at increased risk for colorectal cancer were assigned to receive either 2 g/day ginger or placebo for 28 days. They showed that ginger was tolerable and safe; however, it did not decrease eicosanoid levels in people at increased risk for colorectal cancer (Zick et al., 2015). Moreover, Zick et al. reported no significant difference in eicosanoids level in 30 subjects at normal risk for colorectal cancer.

However, they found a significant decrease in PGE2 and 5-hydroxyeicosatetraenoicacid (HETE) and a trend toward significant decrease in 12-HETE and 15-HETE normalized to free arachidonic acid (Zick et al., 2011).

In another trial, the effects of ginger (2 g for 28 days) on apoptosis, proliferation, and differentiation in the normal-appearing colonic mucosa from 20 patients at increased risk for colorectal cancer showed that ginger supplementation may reduce proliferation in the crypts of normal-appearing colorectal epithelium, increase apoptosis and differentiation relative to proliferation, especially in the differentiation zone of crypts.

This beneficial effect of ginger was found to be associated with downregulation of Bax, human telomerase reverse transcriptase (hTERT), and MIB-1, while p21 and Bcl-2 expression remained relatively unchanged. The estimated treatment effect on MIB-1 was not as strong, the estimated effect was more pronounced in the upper sections of the colorectal crypts, suggesting that ginger may decrease proliferation in the parts of the colorectal crypts most exposed to bowel lumen carcinogens (Citronberg et al., 2013).

These findings are consistent with previous studies that suggested that the chemopreventive properties of ginger may be due to regulate cell function and viability (Keum et al., 2002; Lee & Surh, 1998; Miyoshi et al., 2003; Pan et al., 2008).

In vitro and animal studies also suggest that ginger and its constituents may act as chemopreventive agents by reducing COX-2 expression immune function, lowering the activity of microbial enzymes (β-glucuronidase and mucinase), and blocking angiogenic signals that supply blood to tumor cells (Brown et al., 2009; Khater, 2010; Lu et al., 2011; Seo, Lee, & Kim, 2005; Yagihashi, Miura, & Yagasaki, 2008).

Ginger has anti-inflammatory activities that play roles on its chemopreventive potential against colorectal cancer. In a study on 30 normal participants and 20 participants at increased risk for colorectal cancer, ginger significantly lowered COX-1 protein expression in participants at increased risk for colorectal cancer but not in the participants at normal risk.

However, ginger did not alter 15-hydroxyprostaglandin dehydrogenase (PGDH) protein expression in either increased or normal risk participants (Jiang et al., 2013).

Some findings of other studies about beneficial effects of ginger and its constituents in GI cancer patients included: inhibition of COX and decrease in PGE2 concentrations in colorectal cancer (Levine et al., 2008), reduction in the incidence and multiplicity of adenomas (Zick et al., 2015), decrease in proliferation (hTERT and MIB-1) and differentiation (p21waf1/cip1) in colonocytes (Stoner, 2013), inhibition of CYP450, 1-aminobenzotriazole, and aldo-keto reductase in human liver microsomes, prevention of the formation of M14 and M15 and 18β-glycyrrhetinic acid in human liver microsomes (Chen, Soroka, Zhu, & Sang, 2013).


Dysphagia is a major alarm sign in gastroenterology; however, impaired swallowing function from a combination of underlying disease and reduced physical and cognitive abilities could be a result of elderly. This phenomenon and, in particular, dysphagia are associated with reduced cough reflex leading to increased risk of aspiration

pneumonia (Hirata et al., 2016). Furthermore, it may result in malnutrition, dehydration, and decreasing the patient’s quality of life. The swallowing reflex is controlled by substance P (SP) that released by nerve endings in the bronchial mucosa and oral cavity (Jin et al., 1994; Ujiie, Sekizawa, Aikawa, & Sasaki, 1993).

Reduced salivary SP levels in older people are reported to be lower than in healthy younger individuals (Sekizawa, Ujiie, Itabashi, Sasaki, & Takishima, 1990). Hirata et al. evaluated the application of ginger orally disintegrating (OD) tablets, which prepared by mixing the excipients with the same amount of mannitol and sucrose to a concentration of 1% ginger, on improvement of swallowing function in eighteen healthy older adult aged 63–90.

Saliva was collected and endoscopy was performed before and 15 min after ingestion of the placebo and ginger OD tablets. The results showed that 15 min after taking the ginger OD tablets, salivary SP amount was significantly higher than prior to ingestion or after taking the placebo so that it increased near to what observed in healthy young adults. Moreover, no aspiration occurred and a significant improvement in the swallowing function score was observed.

Prior to this, they had examined OD tablets on 12 healthy adult male and found SP level of saliva increased immediately after oral ingestion and showed a significantly higher concentration of SP in saliva between 15 and 120 min after oral ingestion as compared to placebo.

The mechanism responsible for improving swallowing function is believed to be a result of the gingerol and shogaol components of ginger that act as a TRPV1 agonist (Abe et al., 2015; Hirata et al., 2016). Krival & Bates (2012) measured differences in peak lingua-palatal swallowing pressures, pressure durations, and pressure adjustments in response to two volumes of water and

carbonation (in Schweppes_ Club Soda) and carbonation+gingerol (in Reed’s Extra Ginger Brew) in 20 young adult women. The study showed that stimulus on lingua-palatal swallowing pressure and rising and releasing lingua-palatal pressure duration were greater for carbonation + gingerol and carbonation than for water.


Ginger consumption rarely induces side effects such as mild gastrointestinal complications such as heartburn, belching, bruising or flushing, rash, and gastrointestinal discomfort. Adverse events were generally not significantly higher in the ginger group compared to the control group (Lete & Allué, 2016; Marx et al., 2013).

In a study of 27 healthy volunteers who consumed a single oral dose of 100 mg to 2 g ginger, minor gastrointestinal upset was the major adverse effect (Zick et al., 2009).

Despite previous studies indicating that ginger could interfere with platelet aggregation and cause excessive bleeding (Srivastava, 1986), a recent crossover study of 12 healthy volunteers who consumed 1.2 g of dried ginger rhizome three times per day for 2 weeks, ginger did not affect platelet aggregation and had no effect on the pharmacokinetics or pharmacodynamics of a single 25 mg dose of warfarin taken on day 7 (Jiang et al., 2005).

Viljoen et al. (2014) also reviewed the safety of ginger as a secondary objective in their meta-analysis of nausea and vomiting of pregnancy and found that ginger did not have a risk for side effects or adverse events during pregnancy. In a prospective study,

the pregnancy outcome of 187 women who were exposed to ginger during the first trimester of pregnancy was compared with women who had been exposed to non-teratogenic drugs that were not antiemetic.

There were no statistically significant differences between the two groups in terms of live births spontaneous abortions, therapeutic abortions, birth weight, or gestational age (Portnoi et al., 2003). A larger population-based cohort study in Norway (68,522 women) showed that the use of ginger during pregnancy (1020 women, 1.5%) was not associated with an increased risk of congenital malformations, still birth/perinatal birth, low birth weight, or preterm birth (Heitmann, Nordeng, & Holst, 2013).


Based on evidence from this systematic review, ginger could be considered a harmless and possibly effective alternative option for women suffering from the symptoms of nausea and vomiting in pregnancy. It seems that divided lower daily dosage of 1500 mg ginger is beneficial for nausea relief. Ginger did not pose a risk for side effects or adverse events during pregnancy.

Ginger and its polyphenols have been shown to target multiple signaling molecules that provide a basis for its use against multifactorial human diseases such as cancer. Moreover, most of the known activities of ginger components are based only on in vitro and in vivo studies, except for a few clinical studies in some gastrointestinal disorders especially nausea and vomiting in human subjects and limited number in some other complications that may not be as much powered as to find significant results.

Therefore, more extensive and well-controlled human studies are required to demonstrate its efficacy as gastroprotective agent, as it is a safe and cost-effective alternative. Dose-finding studies should be undertaken to accurately determine the effective dose and preparation of ginger.

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/)


Abe, N., Hirata, A., Funato, H., Nakai, M., Iizuka, M., Yagi, Y., Moriyama, H. (2015). Swallowing function improvement effect of Ginger (Zingiber officinale). Food Science and Technology Research, 21(5), 705–714.
Ali, B. H., Blunden, G., Tanira, M. O., & Nemmar, A. (2008). Some phytochemical, pharmacological and toxicological properties of ginger (Zingiber officinale Roscoe): A review of recent research. Food and Chemical Toxicology, 46(2), 409–420.
Ansari, M., Porouhan, P., Mohammadianpanah, M., Omidvari, S., Mosalaei, A., Ahmadloo, N., Hamedi, S. H. (2016). Efficacy of ginger in control of chemotherapy induced nausea and vomiting in breast cancer patients receiving doxorubicin-based chemotherapy. Asian Pacific Journal of Cancer Prevention, 17(8), 3877–3880.
Apariman, S., Ratchanon, S., & Wiriyasirivej, B. (2006). Effectiveness of ginger for prevention of nausea and vomiting after gynecological laparoscopy. Journal-Medical Association of Thailand, 89(12), 2003.
Arsenault, M., Lane, C., MacKinnon, C., Bartellas, E., Cargill, Y., Klein, M., Wilson, A. (2002). The management of nausea and vomiting of pregnancy. Journal of Obstetrics and Gynaecology Canada, 24(10), 817–831; quiz 832-813.
Arslan, M., & Ozdemir, L. (2015). Oral intake of ginger for chemotherapy-induced nausea and vomiting among women with breast cancer. Clinical Journal of Oncology Nursing, 19(5), E92–E97. Ball, D., Ashley, G., & Stradling, H. (2015). Exercise-induced gastrointestinal disturbances: Potential amelioration with a ginger containing beverage. Proceedings of the Nutrition Society, 74(OCE3), E186.
Basirat, Z., Moghadamnia, A., Kashifard, M., & Sarifi-Razavi, A. (2009). The effect of ginger biscuit on nausea and vomiting in early pregnancy. Acta Medica Iranica, 47(1), 51–56.
Bloechl-Daum, B., Deuson, R. R., Mavros, P., Hansen, M., & Herrstedt, J. (2006). Delayed nausea and vomiting continue to reduce patients’ quality of life after highly and moderately emetogenic chemotherapy despite antiemetic treatment. Journal of Clinical Oncology, 24(27), 4472–4478.
Blumenthal, M. (1998). The Complete German Commission E Monographs.
Boston, MA: Therapeutic Guide to Herbal Medicines.
Brown, A. C., Shah, C., Liu, J., Pham, J. T., Zhang, J. G., & Jadus, M. R. (2009). Ginger’s (Zingiber officinale Roscoe) inhibition of rat colonic adenocarcinoma cells proliferation and angiogenesis in vitro. Phytotherapy Research, 23(5), 640–645.
Chen, H., Soroka, D., Zhu, Y., & Sang, S. (2013). Metabolism of ginger component [6]-shogaol in liver microsomes from mouse, rat, dog, monkey, and human. Molecular Nutrition & Food Research, 57(5), 865–876.
Chittumma, P., Kaewkiattikun, K., & Wiriyasiriwach, B. (2007). Comparison of the effectiveness of ginger and vitamin B6 for treatment of nausea and vomiting in early pregnancy: A randomized double-blind controlled trial. Journal-Medical Association of Thailand, 90(1), 15.
Chrubasik, S., Pittler, M., & Roufogalis, B. (2005). Zingiberis rhizoma: A comprehensive review on the ginger effect and efficacy profiles. Phytomedicine, 12(9), 684–701.
Citronberg, J., Bostick, R., Ahearn, T., Turgeon, D. K., Ruffin, M. T., Djuric, Z., Zick, S. M. (2013). Effects of ginger supplementation on cell-cycle biomarkers in the normal-appearing colonic mucosa of patients at increased risk for colorectal cancer: Results from a pilot, randomized, and controlled trial. Cancer Prevention Research, 6, 271–281.
Dabaghzadeh, F., Khalili, H., Dashti-Khavidaki, S., Abbasian, L., & Moeinifard, A. (2014). Ginger for prevention of antiretroviral-induced nausea and vomiting: A randomized clinical trial. Expert Opinion on Drug Safety, 13(7), 859–866.
Dante, G., Pedrielli, G., Annessi, E., & Facchinetti, F. (2013). Herb remedies during pregnancy: A systematic review of controlled clinical trials. Journal of Maternal-Fetal & Neonatal Medicine, 26(3), 306–312.
Davies, A. R. (2010). Gastric residual volume in the ICU: Can we do without measuring it? Journal of Parenteral and Enteral Nutrition, 34(2), 160–162.
Ding, M., Leach, M., & Bradley, H. (2013). The effectiveness and safety of ginger for pregnancy-induced nausea and vomiting: A systematic review. Women and Birth, 26(1), e26–e30.
Drozdov, V. N., Kim, V. A., Tkachenko, E. V., & Varvanina, G. G. (2012). Influence of a specific ginger combination on gastropathy conditions in patients with osteoarthritis of the knee or hip. Journal of Alternative and Complementary Medicine, 18(6), 583–588.
Emrani, Z., Shojaei, E., & Khalili, H. (2016). Ginger for prevention of antituberculosis-induced gastrointestinal adverse reactions including hepatotoxicity: a randomized pilot clinical trial. Phytotherapy Research., 30, 1003–1009.
Ensiyeh, J., & Sakineh, M.-A. C. (2009). Comparing ginger and vitamin B6 for the treatment of nausea and vomiting in pregnancy: A randomised controlled trial. Midwifery, 25(6), 649–653.
Eslamparast, T., Eghtesad, S., Poustchi, H., & Hekmatdoost, A. (2015). Recent advances in dietary supplementation, in treating non-alcoholic fatty liver disease. World Journal of Hepatology, 7(2), 204–212.
Fahimi, F., Khodadad, K., Amini, S., Naghibi, F., Salamzadeh, J., & Baniasadi, S. (2011). Evaluating the effect of Zingiber officinalis on nausea and vomiting in patients receiving cisplatin based regimens. Iranian Journal of Pharmaceutical Research, 10(2), 379.
Firouzbakht, M., Nikpour, M., Jamali, B., & Omidvar, S. (2014). Comparison of ginger with vitamin B6 in relieving nausea and vomiting during pregnancy. Ayu, 35(3), 289.
Fischer-Rasmussen, W., Kjær, S. K., Dahl, C., & Asping, U. (1991). Ginger treatment of hyperemesis gravidarum. European Journal of Obstetrics & Gynecology and Reproductive Biology, 38(1), 19–24.
Ghochae, A., Hekmat Fshar, M., Amin, G., Ali Vakili, M., Eshghi Nia, S., Sanagoo, A., & Joybari, L. (2013). The survey of the effect of ginger extract on gastric residual volume in mechanically ventilated patients hospitalized in the Intensive Care Units. Advances in Environmental Biology, 7(11), 3395–3400.
Giacosa, A., Guido, D., Grassi, M., Riva, A., Morazzoni, P., Bombardelli, E., Rondanelli, M. (2015). The effect of ginger (Zingiber officinalis) and artichoke (Cynara cardunculus) extract supplementation on functional dyspepsia: A randomised, double-blind, and placebo-controlled clinical trial. Evidence-Based Complementary and Alternative Medicine, 2015(00), 1–9.
Giacosa, A., Morazzoni, P., Bombardelli, E., Riva, A., Bianchi Porro, G., & Rondanelli, M. (2015). Can nausea and vomiting be treated with ginger extract. European Review for Medical and Pharmacological Sciences, 19(7), 1291–1296.
Grøntved, A., Brask, T., Kambskard, J., & Hentzer, E. (1988). Ginger root against seasickness: a controlled trial on the open sea. Acta oto-laryngologica, 105(1–2), 45–49.
Grzanna, R., Lindmark, L., & Frondoza, C. G. (2005). Ginger—an herbal medicinal product with broad anti-inflammatory actions. Journal of Medicinal Food, 8(2), 125–132.
Haji Seid Javadi, E., Salehi, F., & Mashrabi, O. (2013). Comparing the effectiveness of vitamin b6 and ginger in treatment of pregnancy-induced nausea and vomiting. Obstetrics and Gynecology International, 2013(2013), 1–4.
Haniadka, R., Saldanha, E., Sunita, V., Palatty, P. L., Fayad, R., & Baliga, M. S. (2013). A review of the gastroprotective effects of ginger (Zingiber officinale Roscoe). Food & Function, 4(6), 845–855.
Heitmann, K., Nordeng, H., & Holst, L. (2013). Safety of ginger use in pregnancy: Results from a large population-based cohort study. European Journal of Clinical Pharmacology, 69(2), 269–277.
Herrstedt, J., & Dombernowsky, P. (2007). Anti-emetic therapy in cancer chemotherapy: current status. Basic & Clinical Pharmacology & Toxicology, 101(3), 143–150.
Herrstedt, J., & Roila, F. (2008). Chemotherapy-induced nausea and vomiting: ESMO clinical recommendations for prophylaxis. Annals of Oncology, 19(Suppl 2), ii110–ii112.
Hirata, A., Funato, H., Nakai, M., Iizuka, M., Abe, N., Yagi, Y., Hirose, K. (2016). Ginger orally disintegrating tablets to improve swallowing in older people. Biological and Pharmaceutical Bulletin, 39(7), 1107–1111.
Hosseini, F. S., & Adib-Hajbaghery, M. (2015). Ginger essence effect on nausea and vomiting after open and laparoscopic nephrectomies. Nursing and Midwifery Studies, 4(2), e28625.
Hu, M.-L., Rayner, C. K., Wu, K.-L., Chuah, S.-K., Tai, W.-C., Chou, Y.-P., Hu, T.-H. (2011). Effect of ginger on gastric motility and symptoms of functional dyspepsia. World Journal of Gastroenterology, 17(1), 105–110.
Jiang, Y., Turgeon, D. K., Wright, B. D., Sidahmed, E., Ruffin, M. T., Brenner, D. E., Zick, S. M. (2013). Effect of ginger root on cyclooxygenase-1 and 15-hydroxyprostaglandin dehydrogenase expression in colonic mucosa of humans at normal and increased risk of colorectal cancer. European Journal of Cancer Prevention, 22(5), 455.
Jiang, X., Williams, K. M., Liauw, W. S., Ammit, A. J., Roufogalis, B. D., Duke, C. C., … McLachlan, A. J. (2005). Effect of ginkgo and ginger on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects. British Journal of Clinical Pharmacology, 59(4), 425–432.
Jin, Y., Sekizawa, K., Fukushima, T., Morikawa, M., Nakazawa, H., & Sasaki, H. (1994). Capsaicin desensitization inhibits swallowing reflex in guinea pigs. American Journal of Respiratory and Critical Care Medicine, 149(1), 261–263.
Kalava, A., Darji, S. J., Kalstein, A., Yarmush, J. M., SchianodiCola, J., & Weinberg, J. (2013). Efficacy of ginger on intraoperative and postoperative nausea and vomiting in elective cesarean section patients. European Journal of Obstetrics & Gynecology and Reproductive Biology, 169(2), 184–188.
Keating, A., & Chez, R. A. (2002). Ginger syrup as an antiemetic in early pregnancy. Alternative Therapies in Health and Medicine, 8(5), 89.
Keum, Y.-S., Kim, J., Lee, K. H., Park, K. K., Surh, Y.-J., Lee, J. M., Cha, I. H. (2002). Induction of apoptosis and caspase-3 activation by chemopreventive [6]-paradol and structurally related compounds in KB cells. Cancer Letters, 177(1), 41–47.
Khater, D. S. (2010). The influence of ginger as a chemopreventive agent on proliferation and apoptosis in chemically induced oral carcinogenesis. Nature Science, 8, 44–51.
Krival, K., & Bates, C. (2012). Effects of club soda and ginger brew on linguapalatal pressures in healthy swallowing. Dysphagia, 27(2), 228–239.
Landzinski, J., Kiser, T. H., Fish, D. N., Wischmeyer, P. E., & MacLaren, R. (2008). Gastric motility function in critically ill patients tolerant vs intolerant to gastric nutrition. Journal of Parenteral and Enteral Nutrition, 32(1), 45–50.
Lazzini, S., Polinelli, W., Riva, A., Morazzoni, P., & Bombardelli, E. (2016). The effect of ginger (Zingiber officinalis) and artichoke (Cynara cardunculus) extract supplementation on gastric motility: A pilot randomized study in healthy volunteers. European Review for Medical and Pharmacological Sciences, 20(1), 146–149.
Lee, E., & Surh, Y.-J. (1998). Induction of apoptosis in HL-60 cells by pungent vanilloids,[6]-gingerol and [6]-paradol. Cancer Letters, 134(2), 163–168.
Lete, I., & Allué, J. (2016). The effectiveness of ginger in the prevention of nausea and vomiting during pregnancy and chemotherapy. Integrative Medicine Insights, 11, 11.
Levine, M. E., Gillis, M. G., Koch, S. Y., Voss, A. C., Stern, R. M., & Koch, K. L. (2008). Protein and ginger for the treatment of chemotherapy-induced delayed nausea. The Journal of Alternative and Complementary Medicine, 14(5), 545–551.
Lien, H.-C., Sun, W. M., Chen, Y.-H., Kim, H., Hasler, W., & Owyang, C. (2003). Effects of ginger on motion sickness and gastric slow-wave dysrhythmias induced by circular vection. American Journal of Physiology-Gastrointestinal and Liver Physiology, 284(3), G481–G489.
Lohsiriwat, S., Rukkiat, M., Chaikomin, R., & Leelakusolvong, S. (2010). Effect of ginger on lower esophageal sphincter pressure. Medical Journal of the Medical Association of Thailand, 93(3), 366.
Lu, J., Guan, S., Shen, X., Qian, W., Huang, G., Deng, X., & Xie, G. (2011). Immunosuppressive activity of 8-gingerol on immune responses in mice. Molecules, 16(3), 2636–2645.
Mandal, P., Das, A., Majumdar, S., Bhattacharyya, T., Mitra, T., & Kundu, R. (2014). The efficacy of ginger added to ondansetron for preventing postoperative nausea and vomiting in ambulatory surgery. Pharmacognosy Research, 6(1), 52.
Manusirivithaya, S., Sripramote, M., Tangjitgamol, S., Sheanakul, C., Leelahakorn, S., Thavaramara, T., & Tangcharoenpanich, K. (2004). Antiemetic effect of ginger in gynecologic oncology patients receiving cisplatin. International Journal of Gynecological Cancer, 14(6), 1063–1069.
Marx, W., Kiss, N., & Isenring, L. (2015). Is ginger beneficial for nausea and vomiting? An update of the literature. Current Opinion in Supportive and Palliative Care, 9(2), 189–195.
Marx, W. M., Teleni, L., McCarthy, A. L., Vitetta, L., McKavanagh, D., Thomson, D., & Isenring, E. (2013). Ginger (Zingiber officinale) and chemotherapy-induced nausea and vomiting: A systematic literature review. Nutrition Reviews, 71(4), 245–254.
Matthews, A., Dowswell, T., Haas, D., & O’Mathúna, D. (2010). Interventions for nausea and vomiting in early pregnancy. Cochrane Database of Systematic Reviews, 9, 000.
McCarthy, F. P., Lutomski, J. E., & Greene, R. A. (2014). Hyperemesis gravidarum: Current perspectives. International Journal of Women’s Health, 6, 719.
McGee, H. (2007). On food and cooking: The science and lore of the kitchen. New York, NY: Simon and Schuster.
Micklefield, G., Redeker, Y., Meister, V., Jung, O., Greving, I., & May, B. (1999). Effects of ginger on gastroduodenal motility. International Journal of Clinical Pharmacology and Therapeutics, 37(7), 341–346.
Miyoshi, N., Nakamura, Y., Ueda, Y., Abe, M., Ozawa, Y., Uchida, K., & Osawa, T. (2003). Dietary ginger constituents, galanals A and B, are potent apoptosis inducers in Human T lymphoma Jurkat cells. Cancer Letters, 199(2), 113–119.
Mohammadbeigi, R., Shahgeibi, S., Soufizadeh, N., Rezaiie, M., & Farhadifar, F. (2011). Comparing the effects of ginger and metoclopramide on the treatment of pregnancy nausea. Pakistan Journal of Biological Sciences, 14(16), 817–820.
Montazeri, A. S., Hamidzadeh, A., Raei, M., Mohammadiun, M., Montazeri, A. S., Mirshahi, R., & Rohani, H. (2013). Evaluation of oral ginger efficacy against postoperative nausea and vomiting: A randomized, double-blinded clinical trial. Iranian Red Crescent Medical Journal, 15(12), e12268.
Montazeri, A. S., Raei, M., Ghanbari, A., Dadgari, A., Montazeri, A. S., & Hamidzadeh, A. (2013). Effect of herbal therapy to intensity chemotherapy-induced nausea and vomiting in cancer patients. Iranian Red Crescent Medical Journal, 15(2), 101–106.
Mowrey, D., & Clayson, D. (1982). Motion sickness, ginger, and psychophysics. Lancet, 319(8273), 655–657. Ong, J. P., & Younossi, Z. M. (2007). Epidemiology and natural history of NAFLD and NASH. Clinics in Liver Disease, 11(1), 1–16.
Ozgoli, G., Goli, M., & Simbar, M. (2009). Effects of ginger capsules on pregnancy, nausea, and vomiting. Journal of Alternative and Complementary Medicine, 15(3), 243–246.
Palatty, P. L., Haniadka, R., Valder, B., Arora, R., & Baliga, M. S. (2013). Ginger in the prevention of nausea and vomiting: A review. Critical Reviews in Food Science and Nutrition, 53(7), 659–669.
Pan, M. H., Hsieh, M. C., Kuo, J. M., Lai, C. S., Wu, H., Sang, S., & Ho, C. T. (2008). 6-Shogaol induces apoptosis in human colorectal carcinoma cells via ROS production, caspase activation, and GADD 153 expression. Molecular Nutrition & Food Research, 52(5), 527–537.
Panahi, Y., Saadat, A., Sahebkar, A., Hashemian, F., Taghikhani, M., & Abolhasani, E. (2012). Effect of ginger on acute and delayed chemotherapy-induced nausea and vomiting: A pilot, randomized, open-label clinical trial. Integrative Cancer Therapies, 11(3), 204–211.
Pillai, A. K., Sharma, K. K., Gupta, Y. K., & Bakhshi, S. (2011). Anti-emetic effect of ginger powder versus placebo as an add-on therapy in children and young adults receiving high emetogenic chemotherapy. Pediatric Blood & Cancer, 56(2), 234–238.
Pongrojpaw, D., & Chiamchanya, C. (2003). The efficacy of ginger in prevention of post-operative nausea and vomiting after outpatient gynecological laparoscopy. Journal of the Medical Association of Thailand = Chotmaihet Thangphaet, 86(3), 244–250.
Pongrojpaw, D., Somprasit, C., & Chanthasenanont, A. (2007). A randomized comparison of ginger and dimenhydrinate in the treatment of nausea and vomiting in pregnancy. Journal-Medical Association of Thailand, 90(9), 1703.
Portnoi, G., Chng, L.-A., Karimi-Tabesh, L., Koren, G., Tan, M. P., & Einarson, A. (2003). Prospective comparative study of the safety and effectiveness of ginger for the treatment of nausea and vomiting in pregnancy. American Journal of Obstetrics and Gynecology, 189(5), 1374–1377.
Prasad, S., & Tyagi, A. K. (2015). Ginger and its constituents: Role in prevention and treatment of gastrointestinal cancer. Gastroenterology Research and Practice, 00, 1–11.
Rahimlou, M., Yari, Z., Hekmatdoost, A., Alavian, S. M., & Keshavarz, S. A. (2016). Ginger supplementation in nonalcoholic fatty liver disease: A randomized, double-blind, placebo-controlled pilot study. Hepatitis Monthly, 16(1), e34897.
Ryan, J. L. (2010). Treatment of chemotherapy-induced nausea in cancer patients. European Oncology, 6(2), 14.
Ryan, J. L., Heckler, C. E., Roscoe, J. A., Dakhil, S. R., Kirshner, J., Flynn, P. J., Morrow, G. R. (2012). Ginger (Zingiber officinale) reduces acute chemotherapy-induced nausea: A URCC CCOP study of 576 patients. Supportive Care in Cancer, 20(7), 1479–1489.
Saberi, F., Sadat, Z., Abedzadeh-Kalahroudi, M., & Taebi, M. (2014). Effect of ginger on relieving nausea and vomiting in pregnancy: A randomized, placebo-controlled trial. Nursing and Midwifery Studies, 3(1), 000.
Sanaati, F., Najafi, S., Kashaninia, Z., & Sadeghi, M. (2016). Effect of ginger and chamomile on nausea and vomiting caused by chemotherapy in Iranian women with breast cancer. Asian Pacific Journal of Cancer Prevention, 17(8), 4125–4129.
Seidi, J., Ebnerasooli, S., Shahsawari, S., & Nzarian, S. (2017). The influence of oral ginger before operation on nausea and vomiting after cataract surgery under general anesthesia: a double-blind placebo-controlled randomized clinical trial. Electronic Physician, 9(1), 3508.
Sekizawa, K., Ujiie, Y., Itabashi, S., Sasaki, H., & Takishima, T. (1990). Lack of cough reflex in aspiration pneumonia. Lancet, 335(8699), 1228–1229.
Seo, E. Y., Lee, H. S., & Kim, W. K. (2005). Effect of [6]-gingerol on inhibition of cell proliferation in MDA-MB-231 human breast cancer cells. Korean Journal of Nutrition, 38(8), 656–662.
Shariatpanahi, Z. V., Taleban, F. A., Mokhtari, M., & Shahbazi, S. (2010). Ginger extract reduces delayed gastric emptying and nosocomial pneumonia in adult respiratory distress syndrome patients hospitalized in an intensive care unit. Journal of Critical Care, 25(4), 647–650.
Smith, C., Crowther, C., Willson, K., Hotham, N., & McMillian, V. (2004). A randomized controlled trial of ginger to treat nausea and vomiting in pregnancy. Obstetrics & Gynecology, 103(4), 639–645.
Solomon, D. H., & Goodson, N. J. (2007). Nonsteroidal anti-inflammatory drugs for osteoarthritis. In L. Sharma & F. Berenbaum (Eds.), Osteoarthritis: A companion to rheumatology (pp. 178–201). Philadelphia, PA: Elsevier Inc.
Sontakke, S., Thawani, V., & Naik, M. (2003). Ginger as an antiemetic in nausea and vomiting induced by chemotherapy: A randomized, cross-over, double blind study. Indian Journal of Pharmacology, 35(1), 32–36.
Sripramote, M., & Lekhyananda, N. (2003). A randomized comparison of ginger and vitamin B6 in the treatment of nausea and vomiting of pregnancy. Journal of the Medical Association of Thailand = Chotmaihet Thangphaet, 86(9), 846–853.
Srivastava, K. (1986). Isolation and effects of some ginger components on platelet aggregation and eicosanoid biosynthesis. Prostaglandins,
Leukotrienes and Medicine, 25(2–3), 187–198. Stewart, J. J., Wood, M. J., Wood, C. D., & Mims, M. E. (1991). Effects of ginger on motion sickness susceptibility and gastric function. Pharmacology, 42(2), 111–120.
Stoner, G. D. (2013). Ginger: Is it ready for prime time? Cancer Prevention Research, 6(4), 257–262.
Talley, N., Stanghellini, V., Heading, R., Koch, K., Malagelada, J., & Tytgat, G. (1999). Functional gastroduodenal disorders. Gut, 45(suppl 2), II37–II42.
Tavlan, A., Tuncer, S., Erol, A., Reisli, R., Aysolmaz, G., & Otelcioglu, S. (2006). Prevention of postoperative nausea and vomiting after thyroidectomy. Clinical Drug Investigation, 26(4), 209–214.
Thamlikitkul, L., Srimuninnimit, V., Akewanlop, C., Ithimakin, S., Techawathanawanna, S., Korphaisarn, K., … Soparattanapaisarn, N. (2017). Efficacy of ginger for prophylaxis of chemotherapy induced nausea and vomiting in breast cancer patients receiving adriamycin–cyclophosphamide regimen: A randomized, double-blind, placebo-controlled, crossover study. Supportive Care in Cancer, 25(2), 459–464.
Thoma, C., Day, C. P., & Trenell, M. I. (2012). Lifestyle interventions for the treatment of non-alcoholic fatty liver disease in adults: A systematic review. Journal of Hepatology, 56(1), 255–266.
Thomson, M., Corbin, R., & Leung, L. (2014). Effects of ginger for nausea and vomiting in early pregnancy: A meta-analysis. Journal of the American Board of Family Medicine, 27(1), 115–122.
Ujiie, Y., Sekizawa, K., Aikawa, T., & Sasaki, H. (1993). Evidence for substance P as an endogenous substance causing cough in guinea pigs. American Journal of Respiratory and Critical Care Medicine, 148(6), 1628–1632.
Van Tilburg, M. A., Palsson, O. S., Levy, R. L., Feld, A. D., Turner, M. J., Drossman, D. A., & Whitehead, W. E. (2008). Complementary and alternative medicine use and cost in functional bowel disorders: A six month prospective study in a large HMO. BMC Complementary and Alternative Medicine, 8(1), 46.
Van Tilburg, M. A., Palsson, O. S., Ringel, Y., & Whitehead, W. E. (2014). Is ginger effective for the treatment of irritable bowel syndrome? A double blind randomized controlled pilot trial. Complementary Therapies in Medicine, 22(1), 17–20.
Viljoen, E., Visser, J., Koen, N., & Musekiwa, A. (2014). A systematic review and meta-analysis of the effect and safety of ginger in the treatment of pregnancy-associated nausea and vomiting. Nutrition Journal, 13(1), 20.
Vutyavanich, T., Kraisarin, T., & Ruangsri, R.-A. (2001). Ginger for nausea and vomiting in pregnancy: Randomized, double-masked, placebo-controlled trial. Obstetrics & Gynecology, 97(4), 577–582.
Wu, K.-L., Rayner, C. K., Chuah, S.-K., Changchien, C.-S., Lu, S.-N., Chiu, Y.-C., Lee, C.-M. (2008). Effects of ginger on gastric emptying and motility in healthy humans. European Journal of Gastroenterology & Hepatology, 20(5), 436–440.
Yagihashi, S., Miura, Y., & Yagasaki, K. (2008). Inhibitory effect of gingerol on the proliferation and invasion of hepatoma cells in culture. Cytotechnology, 57(2), 129–136.
Zeraati, H., Shahinfar, J., Hesari, S. I., Masrorniya, M., & Nasimi, F. (2016). The effect of ginger extract on the incidence and severity of nausea and vomiting after cesarean section under spinal anesthesia. Anesthesiology and Pain Medicine, 6(5).
Zick, S. M., Ruffin, M. T., Lee, J., Normolle, D. P., Siden, R., Alrawi, S., & Brenner, D. E. (2009). Phase II trial of encapsulated ginger as a treatment for chemotherapy-induced nausea and vomiting. Supportive Care in Cancer, 17(5), 563–572.
Zick, S. M., Turgeon, D. K., Ren, J., Ruffin, M. T., Wright, B. D., Sen, A., Brenner, D. E. (2015). Pilot clinical study of the effects of ginger root extract on eicosanoids in colonic mucosa of subjects at increased risk for colorectal cancer. Molecular Carcinogenesis, 54(9), 908–915.
Zick, S. M., Turgeon, D. K., Vareed, S. K., Ruffin, M. T., Litzinger, A. J., Wright, B. D., Brenner, D. E. (2011). Phase II study of the effects of ginger root extract on eicosanoids in colon mucosa in people at normal risk for colorectal cancer. Cancer Prevention Research, 4(11), 1929–1937.